QSAR Study of 4-Aryl-4H-Chromenes as a New Series of Apoptosis Inducers Using Different Chemometric Tools
نویسندگان
چکیده
منابع مشابه
QSAR study of 4-aryl-4H-chromenes as a new series of apoptosis inducers using different chemometric tools.
The apoptosis-inducing activity data of a series of 4-aryl-4H-chromenes based on three cell lines (human breast cancer cell line T47D, human non-smal cell lung cancer cell line H1299, and human colorectal cancer cell line DLD-1) have been subjected to quantitative structure-activity relationship (QSAR) analysis. A collection of chemometrics methods including multiple linear regression (MLR), fa...
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A linear quantitative structure-activity relationship (QSAR) model is presented for modeling and predicting induction of apoptosis by 4-aryl-4H-chromenes. The model was produced by using the multiple linear regression (MLR) technique on a database that consists of 43 recently discovered 4-aryl-4H-chromenes. Among the 61 different physicochemical, topological, and structural descriptors that wer...
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ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2012
ISSN: 1747-0277
DOI: 10.1111/j.1747-0285.2011.01284.x